NiTech Solutions Continuous and distributed manufacturing monthly newsContinuous/distributed manufacturing monthly news

Free-radical solution polymerization of acrylic acid using continuous

Reaction Chemistry & Engineering publishes work on transitioning free-radical solution polymerization of non-ionized acrylic acid from batch to continuous. Based on a minimum acceptable monomer conversion of 98%, an increase in polymer productivity up to 88% is achieved.

Read journal Reaction Chemistry & Engineering

A Vilsmeier chloroformylation by continuous flow chemistry

The article describes the preparation and use of the Vilsmeier reagent under continuous flow conditions for the preparation of an important intermediate in the synthesis of cyanine dyes.

Read this American Chemical Society paper

Applying a dual catalytic photoredox reaction to synthesize 2-alkyl-N-arylindoles in a continuous flow

This American Chemical Society paper by Vertex Pharmaceuticals describes a “versatile one-pot” procedure for preparing 2-alkyl-substituted N-arylindoles.

Vertex Pharmaceuticals: one-pot process for 2-alkyl-substituted N-arylindoles

Solving PAT quality & regulatory hurdles in continuous manufacturing

This article discusses quality and regulatory hurdles in the lifecycle of a process analytical technology, or PAT, application in combination with continuous manufacturing for small and large molecules.

Overcoming PAT quality/regulatory hurdles in continuous

Emerson and Integra CMS link to accelerate adoption of continuous pharmaceutical manufacturing

Software manufacturer Emerson has signed a joint commercialization agreement with specialty consultancy Integra CMS to provide comprehensive technologies and services for continuous processes in the pharmaceutical industry.

Emerson and Integra CMS link on continuous

Continuous manufacturing market (small molecules and biologics), 2020-2030

This report analyses the current market and future opportunities for companies with capabilities in continuous manufacturing.

Continuous manufacturing study

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EVENTS

4th International Symposium on Continuous Manufacturing of Pharmaceuticals

Postponed to spring 2021. Royal Sonesta Boston Hotel, Cambridge, Massachusetts, USA

The focus of the conference will be on patients and addressing specific implementation barriers to accelerate the adoption of continuous manufacturing.